Neuroanatomic and Connectomic Profiles of Early-Onset Schizophrenia and Autism Spectrum Disorder

21st March, 2024

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Source: Medical Xpress

Schizophrenia (SCZ) and autism spectrum disorder (ASD) are two mental disorders with abnormal neurodevelopment that carry a high burden for families and society. The two disorders exhibit similar clinical symptoms in social interaction, emotional reciprocity, and cognitive deficits.

Therefore, using non-invasive and radiation-free functional MRI (fMRI) to examine the brain structure and functional abnormalities in children with early-onset schizophrenia (EOS) and ASD is of great significance for exploring the brain mechanisms of the diseases and the early diagnosis based on objective biomarkers.

A recent study published in the journal Medicine Plus and based on standardized functional magnetic resonance imaging (fMRI) data from 594 children at five sites, including children with EOS, children with ASD, and normal control, has depicted the neuroanatomic and functional connectomic profiles of EOS and ASD based on brain imaging.

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