[Source:  Pediatrics via Your Therapy Source]
Pediatrics published research on the effects of physical training combined with growth hormone (GH) on muscle thickness and its relationship with muscle strength and motor development in 22 infants with Prader-Willi syndrome (PWS) followed over 2 years.
Muscle thickness was measured using ultrasound.  Muscle strength was assessed using the Infant Muscle Strength meter.  Finally, motor development was evaluated using the Gross Motor Function Measure.
The results indicated the following:
1.  muscle thickness was significantly decreased in the biceps brachii, forearm flexors, quadriceps, and tibialis anterior muscles in infants with PWS and growth hormone treatment increases muscle thickness in infants with PWS.
2.  Muscle thickness changes with increasing age in the biceps brachii and tibialis anterior was similar to typical development
3.  muscle thickness changes in the quadriceps and forearm flexors was higher compared to typical development.
4.  all 4 muscle groups showed significant positive effects of growth hormone on muscle thickness when controlled for age and baseline muscle thickness.
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