How Brain Inflammation in Children May Cause Neurological Disorders

24th October, 2023

27 October 2023, News, Newsletter

[Source: Science Daily]

Severe inflammation in early childhood is a clinically known risk factor for developing autism and schizophrenia. Now, for the first time, scientists from the University of Maryland School of Medicine (UMSOM) have discovered that inflammation alters the development of vulnerable brain cells, and this could have mechanistic links to neurodevelopmental disorders. This finding could lead to treatments for many different childhood-onset neurodevelopmental disorders.

Using single-cell genomics to study the brains of children who died from inflammatory conditions — such as a bacterial or viral infections or asthma — along with those who died from a sudden accident, researchers from the University of Maryland School of Medicine led a study that found inflammation in early childhood prevents specific neurons in the cerebellum from maturing completely. The cerebellum is a brain region responsible for motor control and higher cognitive functions used in language, social skills, and emotional regulation.

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